Outcome evaluation

• Monitor the patient for resolution of symptoms with a goal of 48 to 72 hours to resolution after start of antimicrobial therapy

• If possible, follow-up on susceptibilities of the infecting organism (urine culture)

• Repeat culture is necessary only if symptoms do not acutely abate or reinfection or recurrence occurs

• Depending on chosen antibiotic therapy, evaluate patient based on drug therapy monitoring parameters including those presented in Table 79-4 to optimize therapy and decrease incidence of adverse drug events.

Table 79-4 Monitoring Parameters for Select Antibiotics Used in the Treatment of UTIs

Dmq Ciais ar Drug WhattaMcnlior_Frequency_EndpomT

Table 79-4 Monitoring Parameters for Select Antibiotics Used in the Treatment of UTIs

Dmq Ciais ar Drug WhattaMcnlior_Frequency_EndpomT

Aminoglycos ides

i£r. urine oulpul

Every i-i Ikjjis

Pieventkm d nepJiro!a»tity manilesled by JIÜC Irr 5CI

Aminoglycoside serum «miciHrJiiO"«

Oependi en duration of 1 hejapy. Ai IMM Otut woöWy; (rtöt Trcijucniiy ir evidente <ji dmigirq renji furKTion

Trcu^h saum concentrations less than 2 mflfl. (l«i IhOdn *2 pinol/LfCt ^fruamKin and lew (bar * 3 u«wVL for robiamyclnl or Ueislhan Ümgl or llf untM 1or jrtiiacint'iocietiiwie riiHof neptin?iosi(Hy and (MMOSitliy

Niiiotlur.viio n

] ¡14» profile

Only if renal funclion changing or motte frffiodi; irnifJnssinf)

Nitroiuantoin metabolite? may dccumulale Imenaä insulliciencyjnd lo.Hi to i'h 'ui'f.^Vbi hy; j'.n,:...: if CM 1 les? Nun 40 mtVmm IViernion ei f holestais

Aminog lyiosldei

Ultiofuramon

Tilratychnes

Sulfonamides

SCf

Only rf renal func I ion c haninntj or unliable

Decrease? In gfcimedilai i^ir.me rale Can significant, decrease lheti'i"e corcemi «ion oi the« agents

ClCI. LrMtinipt" rkrj'iX**; Kr.St'iljm'CrO.iliiiiiH:

ClCI. LrMtinipt" rkrj'iX**; Kr.St'iljm'CrO.iliiiiiH:

"slreptomycintonu'nliaticins ire differ«* than l hoy? lis!«J lien;; txxauw W^pmifthlitHl uied tu tr^tl UTK monitoring for Iiis iKh«h is nof included

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