Outcome evaluation

© Patients receiving antibiotic therapy for SSTIs require monitoring for efficacy and safety. Efficacy typically is manifested by reductions in temperature, white blood cell count, erythema, edema, and pain. Initially, signs and symptoms of infection may worsen owing to toxin release from certain organisms (i.e., GAS); however, they should begin to resolve within 48 to 72 hours of treatment initiation. If no response, or worsening infection is noted after the first 3 days of antibiotics, reevaluate the patient.1 Lack of response may be due to a noninfectious or nonbacterial diagnosis, a pathogen not covered by or resistant to current antibiotic therapy, poor patient adherence, drug or disease interactions causing decreased antibiotic absorption or increased clearance, immunodeficiency, or the need for surgical intervention. To ensure the safety of the regimen, dose antibiotics according to renal and hepatic function as appropriate, and monitor for or minimize adverse drug reactions, allergic reactions, and drug interactions.

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