Outcome evaluation

The most successful outcome in TLS is prevention. If the condition is not able to be prevented, the goal of therapy is to avoid renal failure and quickly return electrolytes to normal.

Table 99-15 Comparison of Allopurinol and Rasburicase in TLS

Q'W

Pi^liiS

ÎODSAWP

jilWIMB

OraJ allofxjnrol

Mut &M-ßÜOmgftiay In 1-Ï divided

$(MMfey (generic)

Adjust doie for renal impairment

CitytuprirTi)

doles

Avukl diLSj ¡riyidt.lioininn.TLJtHmxüirit'l

fiedDniK I0mt)/h)fliflyor200-3il0

Monitor fiii rash

mg/m Aiay

IV jlk^njiiiKil

Adult: 2ft)-4i»frt(^ni'AJjv

MdMM

(AlopdmG

fedui«: Jof mg/tTVftLiy

Unserve fof piarlenii coleriwof Hke

oral rnedkalionE

Mixirïiuiïi ÜM4 ■ H» fliiirtüy

fiasburlrase

Ol? mg/HgAdiy foi up lo 5 days

lower doses and abbievlaüect schedules may be

(Eüek)

ustd 10 dctrtiie oar (0.0?. ■ 0.1 mg/iig/ajy]

Mir lanely cause nausea and ■Ajmniiv)

Contraindicated in patients wuh Gtff) deficiency

htmolyiic jnemij

Ki'n raie1, ni hyperuTKkMiy .tyI .nui ividy

lormatkifi

AWT, juerage wholesale-prkH» G6PQ. glucoic t phosphate ddyJiogmasc

■Noiiralired fo; 70 kq patient or body surface area I.7J m .all cost' ate esnmaled and may vary.

AWT, juerage wholesale-prkH» G6PQ. glucoic t phosphate ddyJiogmasc

■Noiiralired fo; 70 kq patient or body surface area I.7J m .all cost' ate esnmaled and may vary.

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