Outcome evaluation

The success of the treatment of FN depends on the adequate recovery of the ANC and either optimal antimicrobial coverage of identified organisms or empiric coverage of unidentified organisms. Monitor the CBC with differential and Tmax (maximum temperature during previous 24 hours) daily. Assess renal and hepatic function at least twice weekly, especially in patients receiving nephrotoxic agents. Vital signs should be taken every 4 hours. Follow-up on blood and urine culture results daily since many cultures do not become positive for several days. Assess the patient daily for pain that may indicate an infectious source. Conduct daily physical examination of common sites of infection. Repeat cultures and chest X-ray in persistently febrile patients and culture developing sources of infection (i.e., stool cultures for diarrhea).

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