P x

where U is the concentration of creatinine in a urine specimen (in same units as P), V is the volume of urine (in mL), P is the concentration of creatinine in serum at the midpoint of the urine collection period (in same units as U), and T is the time of the urine collection period in minutes (e.g., 6 hours = 360 minutes; 24 hours = 1,440 minutes).

*The product of U x V equals the production of creatinine during the collection period and, at steady state, should equal 20 to 25 mg/kg/day for ideal body weight (IBW) in males and 15 to 20 mg/kg/day for IBW in females. If it is less than this, inadequate urine collection may have occurred, and CrCl will be underestimated.

MDRD Formula for Estimating Glomerular Filtration Rate (From the Modification of Diet in Renal Disease Study)3

Conventional calibration MDRD equation [used only with those creatinine methods that have not been recalibrated to be traceable to isotope dilution mass spectrometry (IDMS)]

For creatinine in mg/dL:

X = 186 creatinine-1154 x age-0 203 x constant

For creatinine in |imol/L:

X = 32,788 x creatinine-1154 x age-0 203 x constant where X is the glomerular filtration rate (GFR), constant for white males is 1 and for females is 0.742, and constant for African Americans is 1.21. Creatinine levels in Hmol/L can be converted to mg/dL by dividing by 88.4.

IDMS-Traceable MDRD Equation (Used Only With Creatinine Methods That Have Been Recalibrated to Be Traceable to IDMS)

For creatinine in mg/dL:

X = 175 x creatinine-1154 x age-0 203 x constant

For creatinine in |imol/L:

X = 175 x (creatinine/88.4)-1 154 x age-0 203 x constant where Xis the GFR, constant for white males is 1 and for females is 0.742, and constant for African Americans is 1.21.

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