The infectious dose of EHEC is very low, between 1 and 100 colony-forming units (CFUs).11 The two major virulence factors for EHEC are the production of two Shiga-like cytotoxins (Shiga toxin [Stx] I and II) and adhesion-causing attachment-efface-ment (A/E) lesions. These Stx cytotoxins are responsible for vascular damage and systemic effects such as HUS. Adhesion mediates initial attachment of EHEC to intestinal epithelial cells. Following attachment, these organisms produce A/E lesions on individual intestinal epithelial cells. A/E lesions infect the small or large intestine and cause diarrhea.

The Prevention and Treatment of Headaches

The Prevention and Treatment of Headaches

Are Constant Headaches Making Your Life Stressful? Discover Proven Methods For Eliminating Even The Most Powerful Of Headaches, It’s Easier Than You Think… Stop Chronic Migraine Pain and Tension Headaches From Destroying Your Life… Proven steps anyone can take to overcome even the worst chronic head pain…

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