Pathogenesis

C. difficile is spread by the fecal-oral route, and patient-to-patient transmission has been documented. C. difficile is a gram-positive, spore-forming anaerobe. The organism is ingested either as the vegetative form or spores, which can survive for long periods in the environment and can traverse the acidic stomach. In the small intestine, spores germinate into the vegetative form. In the large intestine, CDAD can develop if the normal flora is disrupted by antibiotic therapy. Toxin production is essential for disease to occur. The main virulence factor for disease related to C. difficile is the production of toxins A and B. These toxins are responsible for inflammation, fluid and mucus secretion, and mucosal damage, which lead to diarrhea or colitis.

Reducing Blood Pressure Naturally

Reducing Blood Pressure Naturally

Do You Suffer From High Blood Pressure? Do You Feel Like This Silent Killer Might Be Stalking You? Have you been diagnosed or pre-hypertension and hypertension? Then JOIN THE CROWD Nearly 1 in 3 adults in the United States suffer from High Blood Pressure and only 1 in 3 adults are actually aware that they have it.

Get My Free Ebook


Post a comment