Pathogenesis

C. difficile is spread by the fecal-oral route, and patient-to-patient transmission has been documented. C. difficile is a gram-positive, spore-forming anaerobe. The organism is ingested either as the vegetative form or spores, which can survive for long periods in the environment and can traverse the acidic stomach. In the small intestine, spores germinate into the vegetative form. In the large intestine, CDAD can develop if the normal flora is disrupted by antibiotic therapy. Toxin production is essential for disease to occur. The main virulence factor for disease related to C. difficile is the production of toxins A and B. These toxins are responsible for inflammation, fluid and mucus secretion, and mucosal damage, which lead to diarrhea or colitis.

The Prevention and Treatment of Headaches

The Prevention and Treatment of Headaches

Are Constant Headaches Making Your Life Stressful? Discover Proven Methods For Eliminating Even The Most Powerful Of Headaches, It’s Easier Than You Think… Stop Chronic Migraine Pain and Tension Headaches From Destroying Your Life… Proven steps anyone can take to overcome even the worst chronic head pain…

Get My Free Audio Book


Post a comment