Pathophysiology

Rhinosinusitis is caused by mucosal inflammation and local damage to mucociliary clearance mechanisms from viral infection or allergy. Increased mucus production and reduced clearance of secretions can lead to blockage of the sinus ostia, or the opening of the sinuses to the upper airway. This environment is ideal for bacterial growth and promotes a cycle of local inflammatory response and mucosal injury characterized

23 25

by increased concentrations of interleukins, histamine, and tumor necrosis factor. '

Factors that contribute to bacterial invasion include nose blowing, reduced local im-

23,28

munity, viral virulence, and nasopharyngeal colonization with bacteria. ' Damage to the host defense system perpetuates bacterial overgrowth and persistence of infection.

The Prevention and Treatment of Headaches

The Prevention and Treatment of Headaches

Are Constant Headaches Making Your Life Stressful? Discover Proven Methods For Eliminating Even The Most Powerful Of Headaches, It’s Easier Than You Think… Stop Chronic Migraine Pain and Tension Headaches From Destroying Your Life… Proven steps anyone can take to overcome even the worst chronic head pain…

Get My Free Audio Book


Post a comment