Pathophysiology

Chronic pancreatitis is an inflammatory process that occurs over a long period of time. The inflammation damages the enzyme-producing cells in the pancreas and can also disrupt or destroy the endocrine function of the pancreas by causing diffuse scarring

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and fibrosis. ' Ethanol abuse may cause precipitation of pancreatic enzymes in the ducts of the pancreas leading to chronic inflammation and damage. Ethanol may also

be directly toxic to pancreatic cells. Counterintuitively, the amount of ethanol con-

sumed does not correlate with the incidence or progression of chronic pancreatitis. A patient who "binge drinks" by consuming large amounts of ethanol over short periods of time is as likely to develop chronic pancreatitis as someone who chronically consumes socially acceptable amounts of alcohol. Patients who die from the first dia gnosed episode of chronic pancreatitis may have had undiagnosed chronic pancreatitis for some time.34

O Long-term sequelae of chronic pancreatitis include dietary malabsorption, impaired glucose tolerance, cholangitis, and potential addiction to opioid analgesics. As patients lose exocrine function of the pancreas, they have decreased ability to absorb lipids and protein ingested with normal dietary intake. Weight loss from nutritional malabsorption is a common symptom of chronic pancreatitis not often seen in acute pancreatitis. Fatty- or protein-containing stools are also common; carbohydrate absorption is usually unaffected. Even though patients with chronic pancreatitis have decreased ability to absorb lipid from the GI tract, there does not appear to be an increased incidence of fat-soluble vitamin deficiency in these patients. 6

How To Reduce Acne Scarring

How To Reduce Acne Scarring

Acne is a name that is famous in its own right, but for all of the wrong reasons. Most teenagers know, and dread, the very word, as it so prevalently wrecks havoc on their faces throughout their adolescent years.

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