The classical concept of mucositis pathophysiology asserts that direct cytotoxicity from chemotherapy or radiation to basal epithelial cells results in ulcerative lesions due to a lack of regeneration. These lesions are further complicated by trauma and/ or microorganism growth. However, the most recent theory of mucositis patho-physiology is more detailed, and involves a multistage, dynamic process that builds

upon the historical model. According to this theory, there are five stages of mucositis: initiation, primary damage response, signal amplification, ulceration, and healing. It is important to note that these stages do not occur sequentially. Rather, they are dynamic and may overlap.

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