CF is a disease of exocrine gland epithelial cells where CFTR expression is prevalent. Normally, these cells transport chloride through CFTR chloride channels with sodium and water accompanying this flux across the cell membrane (Fig. 16-1). CFTR is regulated by protein kinases in response to varying levels of the intracellular second messenger cyclic-3',5'-adenosine monophosphate (cAMP). CFTR also downregulates the epithelial sodium channel, regulates calcium-activated chloride and potassium channels, and may function in exocytosis and formation of plasma membrane molecular complexes and proteins important in inflammatory responses.2 In CF, the CFTR chloride channel is dysfunctional and usually results in decreased chloride secretion and increased sodium absorption, leading to altered viscosity of fluid excreted by the exocrine glands and mucosal obstruction.

Dealing With Asthma Naturally

Dealing With Asthma Naturally

Do You Suffer From ASTHMA Chronic asthma is a paralyzing, suffocating and socially isolating condition that can cause anxiety that can trigger even more attacks. Before you know it you are caught in a vicious cycle Put an end to the dependence on inhalers, buying expensive prescription drugs and avoidance of allergenic situations and animals. Get control of your life again and Deal With Asthma Naturally

Get My Free Ebook

Post a comment