The retrograde movement of acid or other noxious substances from the stomach into the esophagus is a major factor in the development of GERD.4 Commonly, gastroesophageal reflux is associated with defective lower esophageal sphincter (LES) pressure or function. Problems with other normal mucosal defense mechanisms such as anatomic factors, esophageal clearance, mucosal resistance, gastric emptying, epidermal growth factor, and salivary buffering may also contribute to the development of GERD. Other factors that may promote esophageal damage upon reflux into the esophagus include gastric acid, pepsin, bile acids, and pancreatic enzymes. Therapeutic regimens for GERD are designed to maximize normal mucosal defense mechanisms and attenuate these other factors that contribute to the disease.

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Reasons, Remedies And Treatments For Heartburns

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