Pathophysiology Neurochemical

The pathophysiology of bipolar disorder remains incompletely understood. Imaging techniques such as positron emission tomography (PET) scans and functional MRI (fMRI) are being used to elucidate the cause. Research in the 1970s focused on neurotransmitters such as norepinephrine (NE), dopamine (DA), and serotonin. One hypothesis was that bipolar disorder is caused by an imbalance of cholinergic and cat-echolaminergic neuronal activity. Serotonin (5-HT) has been suggested to modulate catecholamine activity. Dysregulation of this relationship could cause a mood disturbance.6 An early theory was that elevation of NE and DA caused mania, and a reduction caused depression, but this theory is now considered overly simplistic. Other neuro-transmitters are involved and interact with multiple neurochemical and neuroanatomic mechanisms and pathways. The pathophysiology of bipolar disorder has also been hypothesized from the mechanisms of action of lithium and other mood stabilizers. Lithium, valproate, and carbamazepine all have similar effects on neuronal growth that are reversible by inositol, supporting the hypothesis that bipolar disorder is related to inos-itol disturbance. Evidence has shown that brain-derived neurotrophic factor (BDNF) may also play a role in bipolar disorder. Serum BDNF is low in mania and improves with response to treatment.8

Bipolar Disorder Uncovered

Bipolar Disorder Uncovered

If you're wanting to learn about bipolar disorder... Then this may be the most important letter you'll ever read! You are about to take an in-depth look at bipolar disorder. It's all you need to know about bipolar disorder to help you or a loved one lead a normal life. It doesn't matter if you or a loved one have been recently diagnosed or been struggling with bipolar disorder for years - This guide will tell you everything you need to know, without spending too much brainpower!

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