Once injured or activated by a toxic substance (e.g., bacterial toxins, placenta chemicals, snake venom, etc.), endothelial cells and monocytes respond by generating tissue factor on the cell surface. Generation of tissue factor-factor VIIa complexes leads to extrinsic pathway activation, excessive generation of thrombin and fibrin, generation of systemic microthrombi, and consumption of coagulation factors and platelets. In addition, inhibition of naturally occurring endothelium-linked anticoagulant pathways (e.g., antithrombin, protein C, and tissue factor pathway inhibitor) and fibrinolytic system (due to a rise in plasminogen activator inhibitor, PAI-1 concentrations) leads to a vast procoagulant state. While bleeding into the subcutaneous tissues, skin, and mucous membranes takes place, microvascular thrombosis exacerbates tissue ischemia 22

and organ damage.

Reducing Blood Pressure Naturally

Reducing Blood Pressure Naturally

Do You Suffer From High Blood Pressure? Do You Feel Like This Silent Killer Might Be Stalking You? Have you been diagnosed or pre-hypertension and hypertension? Then JOIN THE CROWD Nearly 1 in 3 adults in the United States suffer from High Blood Pressure and only 1 in 3 adults are actually aware that they have it.

Get My Free Ebook

Post a comment