Patient Encounter 2 Part 1

A 43-year-old male in the surgical ICU after exploratory laparotomy following a motor vehicle accident develops fever that is unresponsive to broad-spectrum antibacterial therapy (piperacillin-tazobactam 3.75 g every 6 hours, gentamicin 120 mg every 8 hours, and vancomycin 1 g every 12 hours). The patient has a central venous catheter and a Foley catheter. Blood cultures are negative at the time, but the patient has yeast growing in the sputum and urine. Laboratory studies reveal a white blood cell count of 11.3 x 103/mm3 (11.3 x 109/L)

What are this patient's risk factors for developing an invasive fungal infection?

What current evidence suggests that this patient has an invasive fungal infection?

If antifungal therapy is empirically started in this patient, which species need to be treated?

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