Pe

BP 140/98, ht 6' 0" (182 cm), wt 120 kg (264 lb)

What riskfactors andpotential riskfactors for age-related macular degeneration does the patient have?

Based on clinical presentation, AMD is classified as early, intermediate, or advanced.20 Early AMD is characterized by small or intermediate drusen and minimal

macular pigment abnormalities. These patients generally have normal central vis-

ion. Intermediate AMD patients have medium or large drusen in one or both

eyes. Approximately 18% of these patients will progress to advanced AMD within 5 years.20

Advanced AMD is classified as non-neovascular (also called the atropic, nonexud-

22 25

ative, or dry form) or neovascular (the exudative or wet form). ' In the non-neovascular form, the retina and other layers atrophy.25 In the neovascular form, new blood 22 25

vessels appear. ' Generally, vision is already affected when patients progress to ad-

vanced AMD; vision loss is seen in both forms. Ten to twenty percentage of patients with the non-neovascular form will progress to the neovascular form.26 Once one eye develops advanced AMD, 43% of patients will develop neovascular changes or atrophy in the other eye within 5 years.2

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