Pharmacologic Therapy ALL

The treatment for ALL consists of four main elements: Remission induction (the initial tumor reduction leading to morphologic remission), CNS directed treatment and consolidation, delayed intensification, and maintenance phases of treatment all of which are aimed at complete elimination of the residual, but subclinical disease re-

maining after induction (Table 95-8).

Table 95-7 Risk Category According to Cytogenetic Abnormalities Present

DIltilH

Rlik Category

Govd Ftlik

Infvrmitflttc Rifk

HiJjh Rifk

JUWL

tftJlM3??JlWJ: IrMi®

Normal k-siyiviyp^iiiuvYiyii: Hqïldflliito

fOdlplhi liH^iipiypft -5; - Ï1 del

l&l H trisomy 21

dollar. t'iMjmy

iSql:

Ratability ut k ,i|iu»

LCK qhjn (V iHpi.ll n>

(liiMifr ih^n

I Vedr survival

lirealer thin or c^qml to Kitt

40-50%

Lra Ifian or pqual io 20%

ALL

Hyfi«rtpli*dy; KlOtHh ck 6q

tPMÏk IftWlftWeiffi»

AlXitutc lymphotytiC ICtiktfmid: AML4Cu!l" fWJa^iifiOui

Ail.lfflftl Irorll FH>f. 6.

AlXitutc lymphotytiC ICtiktfmid: AML4Cu!l" fWJa^iifiOui

Ail.lfflftl Irorll FH>f. 6.

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