Pharmacologic Therapy4910

^^ Patients infected with gonorrhea often are coinfected with Chlamydia trachomatis and should receive therapy to eradicate both organisms concurrently. While fluoroquinolones and broad-spectrum cephalosporins have been effective in the treatment of gonorrhea, resistant strains of N. gonorrhoeae have still emerged. In the far-eastern countries, as many as 50% of gonococcal strains exhibit decreased susceptibility to fluoroquinolones. Though ciprofloxacin is still an option for treatment, go-nococcal resistance to ciprofloxacin is usually indicative of its resistance to other fluoroquinolones. As a result, monitoring for fluoroquinolone resistance is now essential to ensure proper treatment and to ascertain the maximum time that this class may be employed as a treatment option.

Fluoroquinolones should not be prescribed for infections in MSM, or in those with a history of recent foreign travel or partners' travel, infections acquired in California or Hawaii, or infections in other areas with increased gonococcal resistance.11

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