Pharmacologic Treatment

© Systemic antibiotics are indicated for serious pressure ulcer infections, including those associated with spreading cellulitis, osteomyelitis, or bacteremia.43 Pressure ulcer infections are generally polymicrobial. Thus, antimicrobial agents with a broad spectrum of activity should be initiated and narrowed according to the results of cultures obtained surgically. The duration of treatment is generally 10 to 14 days, unless osteomyelitis is present.43

Mild superficial infections, such as those that present clinically with delayed wound healing or minimal cellulitis, may be treated with topical antimicrobial agents

such as silver sulfadiazine 1% cream or combination antibiotic ointments. Systemic options for more extensive cellulitis are available in Table 73-3.

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