Pharmacologic Treatment

Most bite wounds require antibiotic therapy only when clinical infection is present.

© However, prophylactic therapy is recommended for wounds at higher risk for infection and bites requiring surgical repair 48

© The most effective agent for the treatment (and prophylaxis) of human and animal bite-wound infections is amoxicillin-clavulanate. Alternatives for patients with significant penicillin allergies include either a fluoroquinolone (such as ciprofloxacin) or trimethoprim-sulfamethoxazole in combination with clindamycin. The durations of prophylaxis and treatment generally are 3 to 5 and 10 to 14 days, respectively.1

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