Neuritic or senile plaques are extracellular protein deposits of fibrils and amorphous aggregates of ^-amyloid protein.12 This formed protein is central to the pathogenesis of AD. The ^-amyloid protein is present in a nontoxic, soluble form in human brains. In AD, conformational changes occur that render it insoluble and cause it to deposit into amorphous diffuse plaques associated with dystrophic neuritis.15 Over time, these deposits become compacted into plaques and the ^-amyloid protein becomes fibrillar and neurotoxic. Inflammation occurs secondary to clusters of astrocytes and microglia surrounding these plaques.

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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