Prognostic Factors

The goal of treatment is to match treatment to risk and minimize over- or under-treatment. Children with ALL are sorted into prognostic categories based on clinical and biological features that mirror their risk of relapse. Risk assessment is an important factor in the selection of treatment1 Age, WBC, leukemic cell-surface markers, DNA content, and specific cytogenetic abnormalities predict response to therapy and are used to assign risk and associated treatment. On the basis of these prognostic variables, patients are assigned to one of the three risk groups (e.g., standard-, high-, or very high-risk groups) that determine the aggressiveness of treatment.

The Prevention and Treatment of Headaches

The Prevention and Treatment of Headaches

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