• Leukocytosis

• Hyperbilirubinemia

Septic patients may have an elevated, low, or normal temperature. The absence of fever is common in neonates and elderly patients. Hypothermia is associated with a poor prognosis. Hyperventilation may occur before fever and chills and may lead to respiratory alkalosis. Disorientation and confusion may develop early in septic patients, particularly in the elderly and patients with pre-existing neurologic impairment. Disorientation and confusion may be related to the infection or due to sepsis signs and symptoms (e.g., hypoxia).

Late sepsis represents a slow process that develops over several hours of hemodynamic instability. Signs and symptoms of late sepsis include:

• Lactic acidosis

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