Recommendations During Pregnancy

• Ceftriaxone 125 mg intramuscularly as a single dose plus therapy recommended for coinfection with Chlamydia

• Spectinomycin 2 g intramuscularly as a single dose plus therapy recommended for coinfection with Chlamydia

• Doxycycline and fluoroquinolones are contraindicated

Recommendations for Disseminated Gonococcal Infection (Regimens Should Be Continued for 24 to 48 Hours): Ceftriaxone 1 g intramuscularly or IV every 24 hours or cefotaxime 1 g IV every 8 hours or ceftizoxime 1 g IV every 8 hours or levofloxa-cin 250 mg IV every 24 hours or spectinomycin 2 g intramuscularly every 12 hours

After improvement begins, therapy is then switched to one of the following 7-day oral regimens: Cefixime 400 mg orally twice daily or ciprofloxacin 500 mg orally twice daily or levofloxacin 500 mg orally once daily.

Uncomplicated Infections of the Cervix, Urethra, and Rectum in Children Less Than 45 kg: Ceftriaxone 125 mg intramuscularly as a single dose or spectinomycin 40mg/kg intramuscularly as a single dose or ceftriaxone 50 mg/kg intramuscularly or IV once daily for 7 days in children with bacteremia or arthritis.

Gonococcal Conjunctivitis: Ceftriaxone 1 g intramuscularly once for adults or ceftriaxone 25 to 50 mg/kg IV or intramuscularly as a single dose for ophthalmia neonatorum or infants born to mothers with gonococcal infection as prophylaxis.

Ophthalmic Neonatorum or Prophylactic Treatment for Infants Whose Mothers Have Gonococcal Infection: Ceftriaxone 25 to 50 mg/kg IV or intramuscularly in a single dose, not to exceed 125 mg.

Ophthalmic Neonatorum Prophylaxis: Erythromycin (0.5%) ophthalmic ointment in a single application to the eyes or tetracycline (1%) ophthalmic ointment in a single application to the eyes.

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