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XI Xla

EXTRINSIC PATHWAY

IX IXa VMa villa J, TF

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prothrombin thrombin f

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fibrinogen fibrin^_|

FIGURE 67-1. Cascade model of coagulation demonstrates activation via the intrinsic or extrinsic pathway. This model shows successive activation of coagulation factors proceeding from the top to the bottom where thrombin and fibrin are generated. (PK, prekallikrein; HK, high-molecular weight kininogen; TF, tissue factor.) (From Roberts HR et al. Molecular biology and biochemistry of the coagulation factors and pathways of hemostasis. In: Beutler et al., eds. Williams Hematology. 6th ed. New York: McGraw-Hill; 2001:1409-1434.)

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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