Rx

XI Xla

EXTRINSIC PATHWAY

IX IXa VMa villa J, TF

rxs^

prothrombin thrombin f

Xllla

fibrinogen fibrin^_|

FIGURE 67-1. Cascade model of coagulation demonstrates activation via the intrinsic or extrinsic pathway. This model shows successive activation of coagulation factors proceeding from the top to the bottom where thrombin and fibrin are generated. (PK, prekallikrein; HK, high-molecular weight kininogen; TF, tissue factor.) (From Roberts HR et al. Molecular biology and biochemistry of the coagulation factors and pathways of hemostasis. In: Beutler et al., eds. Williams Hematology. 6th ed. New York: McGraw-Hill; 2001:1409-1434.)

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