FIGURE 91-2. Cross-section of bowel wall. (From DiPiro JT, Talbert RL, Yee GC, et al., eds. Pharmacotherapy: A Patholphysiologic Approach, 6th ed. New York: McGraw-Hill, 2005; Fig. 127-3.)
Over 90% of colorectal cancers that develop are adenocarcinomas and are assigned a grade of I to III based on how similar they are compared to normal colorectal cells. Grade I tumors most closely resemble normal cellular structure, whereas grade III tumors have frequently lost the characteristics of mature normal cells. Grade III tumors are associated with a worse prognosis than grade I turmors.
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