Subset III Cool and

• CI less than 2.2 L/min/m2, PCWP less than 18 mm Hg

• Patients are inadequately perfused and not congested

• Hypoperfusion leads to increased mortality, elevating death rates fourfold compared to those who are adequately perfused

• Treatment focuses on increasing CO with positive inotropic agents and/or replacing intravascular fluids

• Fluid replacement must be performed cautiously, as patients can rapidly become congested

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