Summary

Recent advances in the treatment of cancer of the colon and rectum now offer the potential to improve patient survival but for many patients, improved disease-and progression-free survival represent equally important therapeutic outcomes. In the absence of the ability of a specific treatment to demonstrate improved survival, important outcome measures should include the effects of the treatment on patient symptoms, daily activities, performance status, and other quality-of-life indicators. Individualized patient care to balance the risks associated with treatment and benefits of a specific treatment regimen is necessary to optimize patient outcomes.

Abbreviations Introduced in This Chapter

CA POX Capecftabine and oxa lip latin

CTC Computed tomographic colonoscopy

BPD Dihydropyrimidine dehydrogenase

EGFR Epidermal growth lac lor receptor

FAP Familial adenomatous polyposis

F-dUMP J:luoro-dcoxy-uridine monophosphate

FISH Fluorescence in situ hybridization

FIT fecai immunochemical test

FOLFLRI

Folinic acid* fluorou racily and in fits tonal

irinotecan

FOLFOX

Folink acid, fluorouracil, and oxaliplatin

HNPCC

Hereditary nu ┬╗polyposis colorectal cancer

I PL

Irinotecan, fliiorouraciL and Icucovoiin

IHC

Immunoh iiuochetriical

INK

International Normalised Ratio

NSA IDs

Nonsteroidal anti-inE'IaniEialory drugs

PET

Positron-cmbsdoti Lomography

TNM

Tumor, node, metastasis

TP

Thymidine phwphorylase

UGT

U DP- gtucu ronosy It ra ri sferase

vegf

Vascular endothelial growth factor

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