• Pulmonary: chronic cough, sputum production, decreased exercise tolerance, and recurrent respiratory tract infections (pneumonia and sinusitis). Acute infection may be marked by increased cough, changes in sputum (darker and thicker), dyspnea, and fever

• Gl: numerous large, foul-smelling loose stools (steatorrhea), flatulence, and abdominal pain. Intestinal obstruction may present as abdominal pain and distention and/ or decreased bowel movements

• Nutritional: poor weight gain, voracious appetite, and hunger. Dry skin, skin rash, and visual disturbances may be noted in vitamin deficiency

• CFRD: weight loss, increased thirst, and more frequent urination

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