• Cessation of menses

• Possible complaints of infertility, vaginal dryness, decreased libido Signs

• Cessation of menses for longer than 6 months in women with established menstruation, or absence of menses by age 16 in the presence of normal secondary sexual development, or absence of menses by age 14 in the absence of normal secondary sexual development

• Recent significant weight loss or weight gain

• Presence of acne, hirsutism, hair loss, or acanthosis nigricans may suggest androgen excess

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