Neurofibrillary tangles are intracellular and consist of abnormally phosphorylated t protein, which is involved in microtubule assembly. Tangles interfere with neuronal function, resulting in cell damage, and their presence has been correlated with the severity of dementia.13 Unfortunately, these tangles are insoluble even after the cell dies, and they cannot be removed once established. The neurons that provide most of the cholinergic innervation to the cortex are most prominently affected.14 Therefore, prevention is the key to targeted therapy of these tangles.

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