Tertiary Syphilis Drug of Choice

Benzathine penicillin 2.4 million units administered intramuscularly once weekly for 3 weeks.

Alternatives

In nonpregnant patients with a penicillin allergy, alternative regimens include doxycycline 100 mg orally two times daily for 4 weeks or tetracycline 500 mg orally four times daily for 4 weeks.

Postivo syphilis scroervng «warn

Perorm treponemal specific tesl

1

PoMrve treponemai-speofic test

Negative troponcmal-spestic test

——i

stage cf iniect>on; obtain test tost rose*

stage cf iniect>on; obtain test

Sgns or symptoms o< f or soconda ry

No dinical signs or symptoms (talent sypMis)

Benzathine Pontc*n G. 2.4 million units IM (sin^o dose)*

S«gis o< symptoms cA tertary (late) syphilis. HW-posit ivo patient

Of OthOfVWSO

mmunooompfomtted

Early latent Late latent

S«gis o< symptoms cA tertary (late) syphilis. HW-posit ivo patient

Of OthOfVWSO

mmunooompfomtted

Benzathine peooHm G. 2.4 milkon units IM

tost rose*

Conader other causes

Benzathine peooHm G. 2.4 milkon units IM

BenzatNne peraofen G. 2.4 mribon units IM once weekly tor3weefcs (3 dosos)

puncturo

Sgns. symptoms.

CSF findings consistent with neurosyphAs

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