Three Months and Beyond

1. Measure PT/INR every 1 to 4 weeks based on the stability of the INR and patient's health status.

2. Interview the patient to determine if there is worsening or new symptoms related to VTE. Inquire about and evaluate patient adherence to therapy. Ask the patient about overt bruising or bleeding as well as changes in stool or urine color. Reinforce previous patient education regarding vitamin K intake and potential drug-drug interactions with warfarin.

3. Reevaluate the risks and benefits of continuing warfarin therapy.

4. Document activities in medical record.

Abbreviations Introduced in This Chapter

ABW

Adjusted body weight

ACCP

American College of Chest Physicians

ACT

Activated clotting time

ADP

Adcnosi nc d i phosphate

rtPTT

Activated partial thromboplastin time

AT

Antithrombin

BMI

Body maä£ index

CrCl

Creatinine clearance

CYIJ

Cytochrome 3J-450 isoenzyme

DTI

Direct thrombin inhibitor

DVT

Deep vein thrombosis

HSR

Erythrocyte sedimentation rate

GCS

Graduated compression stockings

GFR

Glomerular filtration rate

CP

Glycoprotein

HCII

Heparin cofactor 31

HIT

Heparin-induced thrombocytopenia

HK

High-molecular weight kininogen

IBW

Ideal body weight

ICH

Intracranial hemorrhage

IM

Intramuscular

INR

International Normalized Ratio

IPC

Intermittent pneumatic compression (device)

ISI

International Sensitivity Index

IVC

Inferior vena cava

LMWH

Low-molecular weight heparin

PAF

Platelet activating facte>r

PAI-I

P!asm\nin acti val<ir inhibitor-1

PCI

Pert ii tan eous coro na r v i nler vc n 1 ion

PE

Pulmonary e m hol is m

PF-4

Platelet factor-4

PGGtVGH

Prostaglandins

PLA

Phosphotipase A

PT

Prothrombin time

FTS

Post-thrombotic syndrome

SßP

Systolic blood pressure

SC

Subcutaneous

SERM

Selective estrogen receptor modulator

tfpi

t issue factor pathway inhibitor

t-PA

] i ssu e piasm i nogcn act i vato r

TS

I hromboocane synthetase

TXA

Thromboxane A

UFH

Un fractionated heparin

u-PA

Urokinase plasminogen activator

V/Q

Veil Li lation/perfusion (sc an)

VTE

Venous thromboembolism

vWF

von Willebrand s factor

^ Self-assessment questions and answers are available at ht-tp://www. mhpharmacotherapy. com/pp.html.

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