Thrombotic thrombocytopenic pupura Etiology and Epidemiology

Thrombotic thrombocytopenic purpura (TTP) is a severe systemic disorder characterized by the thrombi formation within the circulation that results in the platelet consumption and subsequent thrombocytopenia. Acute idiopathic TTP is more common in women and African Americans, and most frequently occurs in people between 3032

and 40-years-old. The estimated annual incidence of TTP is 3.8 cases per million. Common conditions associated with TTP are summarized in Table 67-10.

Table 67-10 Conditions Associated with TTP

• Infections

Bacterial, fungal, viral, atypical

• Transplantation

Solid organ or bone marrow

• Malignancy

• Collagen vascular diseases

• Medications

Antineoplastic agents, ticlopidine, clopidogrel, antibiotics, immunosuppressants, others

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