Thrombotic thrombocytopenic pupura Etiology and Epidemiology

Thrombotic thrombocytopenic purpura (TTP) is a severe systemic disorder characterized by the thrombi formation within the circulation that results in the platelet consumption and subsequent thrombocytopenia. Acute idiopathic TTP is more common in women and African Americans, and most frequently occurs in people between 3032

and 40-years-old. The estimated annual incidence of TTP is 3.8 cases per million. Common conditions associated with TTP are summarized in Table 67-10.

Table 67-10 Conditions Associated with TTP

• Infections

Bacterial, fungal, viral, atypical

• Transplantation

Solid organ or bone marrow

• Malignancy

• Collagen vascular diseases

• Medications

Antineoplastic agents, ticlopidine, clopidogrel, antibiotics, immunosuppressants, others

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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