To Prevent Hypercortisolism and Development of Cushings Syndrome

• Give the lowest glucocorticoid dose that will manage the disease being treated and for the shortest possible duration

• If feasible, give glucocorticoid via administration routes that minimize systemic absorption (such as inhalation or dermal)

• If feasible, administer glucocorticoid treatment every other day (calculate the total 48-hour dose and give as a single dose of intermediate-acting glucocorticoid in the morning)4

• Avoid concurrent administration of drugs that can inhibit glucocorticoid metabolism

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