Treatment Desired Outcomes

O The primary goals of management of TLS are: (a) prevention of renal failure; (b) prevention of electrolyte imbalances. Thus, the best treatment for TLS is prophylaxis to enable delivery of cytotoxic therapy for the underlying malignancy. For patients that present with or develop TLS despite prophylaxis, treatment goals include: (a) decreasing uric acid levels; (b) correcting electrolyte imbalances; (c) preventing compromised renal function. These goals should be achieved in a cost-effective manner.

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