Upon completion of the chapter the reader will be able to

1. Describe the reasons for solid-organ transplantation.

2. Differentiate between the functions of cell-mediated and humoral immunity and how they relate to organ transplant.

3. Describe the roles of the antigen-presenting cells (APCs) in initiating the immune response.

4. Compare and contrast the types of rejection including hyperacute, acute, chronic, and humoral rejection.

5. Define the terms "host-graft adaptation" and "tolerance," paying close attention to their differences.

6. Discuss the desired therapeutic outcomes and appropriate pharmacotherapy utilized to avoid allograft rejection.

7. Compare and contrast the currently available immunosuppressive agents in terms of mechanisms of action, adverse events, and drug-drug interactions (DDIs).

8. Design an appropriate therapeutic regimen for the management of immunosuppressive drug complications based on patient-specific information.

9. Develop a therapeutic drug-monitoring plan to assess effectiveness and adverse events of the immunosuppressive drugs.

10. Write appropriate patient education instructions and identify methods to improve patient adherence following transplantation.

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Your Heart and Nutrition

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