Upon completion of the chapter the reader will be able to

1. Recognize that antimicrobial resistance is an inevitable consequence of antimicrobial therapy.

2. Describe how antimicrobials differ from other drug classes in terms of their effects on individual patients as well as on society as a whole.

3. Identify two guiding principles to consider when treating patients with antimicrobials, and apply these principles in patient care.

4. Differentiate between microbial colonization and infection based on patient history, physical examination, and laboratory and culture results.

5. Evaluate and apply at least six major drug-specific considerations when selecting antimicrobial therapy.

6. Evaluate and apply at least seven major patient-specific considerations when selecting antimicrobial therapy.

7. Select empirical antimicrobial therapy based on spectrum-of-activity considerations that provide a measured response proportional to the severity of illness. Provide a rationale for why a measured response in antimicrobial selection is appropriate.

8. Identify and apply five major principles of patient education and monitoring response to antimicrobial therapy.

9. Identify two common causes of patients failing to improve while on antimicrobials, and recognize other less common but potential reasons for antimicrobial failure.

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