Upon completion of the chapter the reader will be able to

1. Describe the pathogenesis of acute leukemia.

2. Compare the classification systems for acute lymphocytic leukemia (ALL) and acute myelogenous leukemia (AML).

3. Identify the risk factors associated with a poor outcome for the acute leukemias.

4. Explain the importance of minimal residual disease (MRD) and its implication on early bone marrow relapse.

5. Explain the role of induction, consolidation, and maintenance phases for acute leukemia.

6. Define the role of CNS preventive therapy for acute leukemia.

7. Recognize the treatment complications associated with therapy for acute leukemi-as.

8. Describe the late effects associated with the treatment of long-term survivors of acute leukemias.

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