Upon completion of the chapter the reader will be able to

1. Identify risk factors and signs and symptoms of deep vein thrombosis (DVT) and pulmonary embolism (PE).

2. Describe the processes of hemostasis and thrombosis, including the role of the vascular endothelium, platelets, coagulation cascade, and thrombolytic proteins.

3. Determine a patient's relative risk (low, moderate, or high) of developing venous thrombosis.

4. Formulate an appropriate prevention strategy for a patient at risk for DVT.

5. State at least two potential advantages of the low-molecular weight heparins (LMWHs) and fondaparinux over unfractionated heparin (UFH).

6. Select and interpret laboratory test(s) to monitor antithrombotic drugs.

7. Identify factors that place a patient at high-risk of bleeding while receiving antithrombotic drugs.

8. Identify warfarin drug-drug and drug-food interactions.

9. Manage a patient with an elevated International Normalized Ratio (INR) with or without bleeding.

10. Formulate an appropriate treatment plan for a patient who develops a DVT or PE, and develop a comprehensive education plan for a patient who is receiving an an-tithrombotic drug.

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