What is demineralized bone matrix DBM

DBM is an osteoconductive scaffold produced by acid extraction of banked bone. It lacks structural mechanical properties. Its constituents include noncollagenous proteins, osteoinductive growth factors, and type 1 collagen. DBM is more osteoinductive than allograft bone because the demineralization process makes growth factors (BMPs) more accessible. Clinical data support the use of DBM as a bone graft extender or enhancer in posterior spinal fusion procedures performed with autograft bone. It is not intended to be used in isolation as a bone graft substitute. Few studies address its efficacy in anterior spinal fusion procedures. Significant variation in the biologic activity of DBM preparations has been documented. Bioassays are available to assess osteoinductivity, although no accepted standards exist.

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