What is the role of bisphosphonates in treatment of metastatic spinal disease

Bisphosphonates are useful for controlling bone pain due to metastatic tumor and also decrease the incidence of skeletal-related complications such as pathologic fracture and hypercalcemia of malignancy. Metastatic tumor cells secrete cellular modulators including parathyroid hormone-related protein receptor activator for nuclear factor k B ligand (RANKL), and serine protease urokinase, which exert their effect through stimulation of osteoclasts. Bisphosphonates function by binding to bone matrix and lead to osteoclast dysfunction and apoptosis.

How To Win Your War Against Back Pain

How To Win Your War Against Back Pain

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