Brett S Carver MD Hikmat AlAhmadie MD Joel Sheinfeld MD

Department of Urology and Pathology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue,

New York, NY 10021, USA

Testicular cancer is the most common malignancy in men 20 to 35 years of age and accounts for approximately 1% of all male malignancies. The American Cancer Society [1] estimates that in 2006 there will be 8250 new cases of testicular cancer in the United States and approximately 370 men will die of the disease. The successful multi-disciplinary approach for the management of testicular cancer has resulted in survival rates of greater than 90% overall [2]. Germ-cell tumors (GCT) of the testis can be divided into two major subgroups based on histology: seminoma and nonseminoma. Nonseminomatous histologies including embryonal cell carcinoma, yolk sac tumor, choriocarcinoma, and teratoma account for approximately 50% of all GCT. In approximately 60% of cases, more than one histologic pattern is identified, with the most frequent combination being embryonal carcinoma, yolk sac tumor, and teratoma. In its pure form, teratomas compromise approximately 3% of testicular GCT in adults and 38% of tumors in infants and children [3,4]. Ter-atoma has diverse biologic potential unrelated to the degree of maturity of the histologic components. In this review we will discuss the histologic variants, clinical management, and implications of teratoma.

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