Late effects of cisplatinbased chemotherapy

For many patients who have GCT, cisplatin-based chemotherapy is required for cure. Because patients who have GCT are usually young and are likely to become long-term survivors, issues related to long-term complications of this treatment are important. Cisplatin-based chemotherapy for patients who have GCT may be associated with long-term consequences that may affect several organ systems (Box 3). A review concerning the medical management of the long-term GCT survivor has recently been published [19].

The most studied late effect of cisplatin-based chemotherapy in patients who have GCT is cardiovascular risk. Raynaud phenomenon has been reported in patients who have GCT treated with cisplatin-based chemotherapy [20]. Serious vascular complications (eg, myocardial infarction, stroke, thromboembolic disease) have been reported in patients who had GCT treated with cis-platin-based chemotherapy [21-23]. Larger series have examined the risk for cardiovascular events

Box 3. Potential late effects of cisplatin-based chemotherapy in germ cell tumor survivors

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