Blood pressure

Overdosing androgens, as can be observed during misuse of testosterone and anabolic steroids, may increase blood pressure by increasing blood electrolytes and water retention, leading to edema. During effective testosterone substitution therapy in hypogonadal men such side-effects are not observed (e.g. Whitworth et al. 1992). However, all androgens cause some degree of sodium retention and a small expansion of extracellular fluid volume that may contribute to weight increase in healthy individuals. Regular blood pressure measurement should be performed during testosterone therapy, especially during inception of treatment when the testosterone dosages have to be adjusted, and in men with additional problems of the heart and kidneys (Gooren 1994).

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