In agreement with the association of testosterone and male sex with higher left ventricular mass as well as with the stimulating effect of exogenous testosterone on heart weight and contractility, testosterone was found to induce proliferation of isolated cardiomyocytes. This is in contrast to the antiproliferative effect of estrogens, which therefore suggests a direct effect of testosterone. This was also shown directly (Marsh et al. 1998). By contrast, the similar effect of testosterone and estradiol on the expression of the V1 myosin heavy chain isoenzyme may point to the importance of estradiol and the estrogen receptor for mediating this effect, although this was not shown directly (Lengsfeld etal. 1988; Morano etal. 1990).
Was this article helpful?