Effects of testosterone on platelet function

Aggregation of platelets is a prerequisite for thrombus formation and hence a critical step in acute coronary events (Ruggeri 2002). Administration of testosterone cypionate to eugonadal men led to enhanced ex vivo platelet aggregation in response to the thromboxane analogue I-BOP but not in response to thrombin (Ajayi et al. 1995). Testosterone increases the expression of the androgen receptor in a megakaryocyte cell line, as well as in platelets (Matsuda et al. 1993; 1994). Flutamide inhibited the stimulatory effect of testosterone on thromboxane receptor expression (Matsuda etal. 1993; 1994) suggesting that the effect is mediated via the androgen receptor.

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