General background

Many of the clinical features of aging in men are reminiscent of the clinical changes seen in hypogonadism in young men. It seems a reasonable working hypothesis that some of these clinical changes are causally related to declining Leydig cell function. Unfortunately, this possibility has not been fully explored and it is equally plausible that many of the observed changes and the age-related decrease in serum testosterone levels are coincident and independent consequences of aging.

Cross-sectional studies revealed mostly only weak correlations between androgen status and clinical parameters. The studies examining the effects of androgen treatment in elderly men provide precious information, but should be interpreted with caution as beneficial effects of pharmacological intervention do not imply that the corrected clinical symptoms were due to pre-existent androgen deficiency.

Carefully performed longitudinal observational studies, on the other hand, should provide more definitive answers in the future. In any case, the decreased androgen levels can at best contribute to some of the clinical changes in aging men.

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Hair Loss Prevention

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