GF Weinbauer M Niehaus and E Nieschlag

Contents

5.1

Rationale

5.2

Organisation and kinetics of spermatogenesis

5.2.1

Basic and common features

5.2.2

Species-specific features

5.3

The hypothalamo-hypophyseal-testicular circuit

5.4

Androgen dependence of spermatogenesis

5.4.1

Neonatal androgen secretion

5.4.2

Pubertal initiation of spermatogenesis

5.4.3

Adult spermatogenesis: maintenance and reinitiation

5.5

Androgen action on spermatogenesis

5.5.1

Testicular androgen production, metabolism and transport

5.5.2

Testicular androgen concentrations and spermatogenesis

5.5.3

Testicular androgen receptor and sites of androgen action

5.6

Follicle-stimulating hormone (FSH) and spermatogenesis

5.6.1

FSH receptor and sites of FSH action

5.6.2

FSH dependence of spermatogenesis

5.7

Endocrine control of spermatogenesis

5.7.1

Synergistic and differential action of androgens and FSH on testicular functions

5.8

Androgens and FSH: is there primacy for spermatogenesis?

5.9

Clinical relevance of animal models for the study of androgen actions

5.10

Key messages

5.11

References

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