Short-term controlled studies of androgen therapy in men with alcoholic hepatitis do not provide convincing evidence of any benefit. A prospective randomised multicentre Veterans Administration study claimed a mortality benefit after 30 days of oxandrolone treatment (80 mg daily), compared with placebo in 263 men presenting with alcoholic hepatitis (Mendenhall et al. 1984). The poorly defined entry and end-point definitions have been criticised (Maddrey 1986) and the benefits, if any, appeared to be short-term. The same authors reported a further study of 271 poorly nourished men with alcoholic hepatitis randomised to treatment with oxandrolone plus high calorie food supplements compared with a group receiving placebo without dietary supplementation (Mendenhall etal. 1993). This study showed no overall survival benefit by an intention-to-treat analysis; however, subgroup analysis demonstrated a significant doubling of survival at one month, which persisted for six months in those with "moderate" but not severe malnutrition at entry. Due to the study design, the benefit of androgen therapy relative to enhanced nutrition could not be resolved. Another randomised controlled study of 19 men and 20 women with alcoholic hepatitis treated with 80 mg oxandrolone, parenteral nutrition, both or neither for 21 days demonstrated modest improvement in hepatic biochemical function but did not report other clinical end-points (Bonkovsky etal. 1991).

Hair Loss Prevention

Hair Loss Prevention

The best start to preventing hair loss is understanding the basics of hair what it is, how it grows, what system malfunctions can cause it to stop growing. And this ebook will cover the bases for you. Note that the contents here are not presented from a medical practitioner, and that any and all dietary and medical planning should be made under the guidance of your own medical and health practitioners. This content only presents overviews of hair loss prevention research for educational purposes and does not replace medical advice from a professional physician.

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